Reactivity to bacterial, fungal, and parasite antigens in patients with lymphedema and elephantiasis
Identifieur interne : 009875 ( Main/Exploration ); précédent : 009874; suivant : 009876Reactivity to bacterial, fungal, and parasite antigens in patients with lymphedema and elephantiasis
Auteurs : Jill B. Baird [États-Unis, Haïti] ; Jacky Louis Charles ; Thomas G. Streit ; Jacquelin M. Roberts ; David G. Addiss ; Patrick J. LammieSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 2002.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Agranulocytes (immunologie), Antigènes, Antigènes bactériens, Antigènes d'helminthe, Antigènes fongiques, Enfant, Femelle, Filariose lymphatique (anatomopathologie), Filariose lymphatique (immunologie), Haïti (épidémiologie), Humains, Hypersensibilité retardée (diagnostic), Hypersensibilité retardée (épidémiologie), Lymphoedème (anatomopathologie), Lymphoedème (immunologie), Prévalence, Sujet âgé, Tests cutanés, Évolution de la maladie.
- MESH :
- anatomopathologie : Filariose lymphatique, Lymphoedème.
- diagnostic : Hypersensibilité retardée.
- immunologie : Agranulocytes, Filariose lymphatique, Lymphoedème.
- épidémiologie : Haïti, Hypersensibilité retardée.
- Pascal (Inist)
- Adolescent, Adulte, Adulte d'âge moyen, Antigènes, Antigènes bactériens, Antigènes d'helminthe, Antigènes fongiques, Bactérie, Enfant, Femelle, Humains, Lymphoedème, Fungi, Parasite, Antigène, Homme, Pathogénie, Prévalence, Réponse immune, Hypersensibilité retardée, Immunité cellulaire, Immunité humorale, Eléphantiasis, Exploration immunologique, Sujet âgé, Tests cutanés, Évolution de la maladie.
- Wicri :
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Antigen, Antigens, Antigens, Bacterial, Antigens, Fungal, Antigens, Helminth, Bacteria, Cellular immunity, Child, Delayed hypersensitivity, Disease Progression, Elephantiasis, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (pathology), Female, Fungi, Haiti (epidemiology), Human, Humans, Humoral immunity, Hypersensitivity, Delayed (diagnosis), Hypersensitivity, Delayed (epidemiology), Immune response, Immunological investigation, Leukocytes, Mononuclear (immunology), Lymphedema, Lymphedema (immunology), Lymphedema (pathology), Middle Aged, Parasite, Pathogenesis, Prevalence, Skin Tests.
- MESH :
- chemical : Antigens, Antigens, Bacterial, Antigens, Fungal, Antigens, Helminth.
- geographic , epidemiology : Haiti.
- diagnosis : Hypersensitivity, Delayed.
- epidemiology : Hypersensitivity, Delayed.
- immunology : Elephantiasis, Filarial, Leukocytes, Mononuclear, Lymphedema.
- pathology : Elephantiasis, Filarial, Lymphedema.
- Adolescent, Adult, Aged, Child, Disease Progression, Female, Humans, Middle Aged, Prevalence, Skin Tests.
Abstract
Both secondary infections and antifilarial immunity are thought to play roles in the development and progression of lymphedema. To investigate this issue, immune responses to a panel of bacterial, fungal, and parasite antigens were examined for women with lymphedema and elephantiasis (n = 28) and for women with no clinical evidence of lymphatic dysfunction who were either microfilaremic (Mf+, n = 23) or microfilaria- and filarial antigen-negative (Ag-, n = 24). The prevalence and intensity of delayed-type hypersensitivity (DTH) responses was similar for most recall antigens; for individual antigens, lymphedema patients were significantly more likely to be reactive only to Proteus. Lymphedema patients with a history of three or more attacks of adenolymphangitis in the last 18 months showed increased DTH reactivity to Trichophyton. Proliferative responses to fungal and bacterial antigens were similar for all three groups; however, antigen-negative women, independent of disease status, mounted greater responses to filarial antigen. In contrast, lymphedema patients had higher levels of antifilarial specific IgG1, IgG2, and IgG3 and higher IgG responses to streptolysin O than either Ag- or Mf+ women. In persons with lymphatic filariasis, immune reactivity is influenced by disease status as well as infection status.
Affiliations:
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Baird</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hopital Ste. Croix</s1><s2>Leogane</s2><s3>HTI</s3></inist:fA14><country>Haïti</country><wicri:noRegion>Hopital Ste. Croix</wicri:noRegion></affiliation><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Cellular Biology, University of Georgia</s1><s2>Athens, Georgia</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Division of Parasitic Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, Georgia</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Charles, Jacky Louis" sort="Charles, Jacky Louis" uniqKey="Charles J" first="Jacky Louis" last="Charles">Jacky Louis Charles</name></author><author><name sortKey="Streit, Thomas G" sort="Streit, Thomas G" uniqKey="Streit T" first="Thomas G." last="Streit">Thomas G. 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(immunology)</term><term>Elephantiasis, Filarial (pathology)</term><term>Female</term><term>Fungi</term><term>Haiti (epidemiology)</term><term>Human</term><term>Humans</term><term>Humoral immunity</term><term>Hypersensitivity, Delayed (diagnosis)</term><term>Hypersensitivity, Delayed (epidemiology)</term><term>Immune response</term><term>Immunological investigation</term><term>Leukocytes, Mononuclear (immunology)</term><term>Lymphedema</term><term>Lymphedema (immunology)</term><term>Lymphedema (pathology)</term><term>Middle Aged</term><term>Parasite</term><term>Pathogenesis</term><term>Prevalence</term><term>Skin Tests</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agranulocytes (immunologie)</term><term>Antigènes</term><term>Antigènes bactériens</term><term>Antigènes d'helminthe</term><term>Antigènes fongiques</term><term>Enfant</term><term>Femelle</term><term>Filariose lymphatique (anatomopathologie)</term><term>Filariose lymphatique (immunologie)</term><term>Haïti (épidémiologie)</term><term>Humains</term><term>Hypersensibilité retardée (diagnostic)</term><term>Hypersensibilité retardée (épidémiologie)</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (immunologie)</term><term>Prévalence</term><term>Sujet âgé</term><term>Tests cutanés</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antigens</term><term>Antigens, Bacterial</term><term>Antigens, Fungal</term><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Haiti</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypersensitivity, Delayed</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hypersensibilité retardée</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hypersensitivity, Delayed</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Agranulocytes</term><term>Filariose lymphatique</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Leukocytes, Mononuclear</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Haïti</term><term>Hypersensibilité retardée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Child</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Middle 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xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Both secondary infections and antifilarial immunity are thought to play roles in the development and progression of lymphedema. To investigate this issue, immune responses to a panel of bacterial, fungal, and parasite antigens were examined for women with lymphedema and elephantiasis (n = 28) and for women with no clinical evidence of lymphatic dysfunction who were either microfilaremic (Mf+, n = 23) or microfilaria- and filarial antigen-negative (Ag-, n = 24). The prevalence and intensity of delayed-type hypersensitivity (DTH) responses was similar for most recall antigens; for individual antigens, lymphedema patients were significantly more likely to be reactive only to Proteus. Lymphedema patients with a history of three or more attacks of adenolymphangitis in the last 18 months showed increased DTH reactivity to Trichophyton. Proliferative responses to fungal and bacterial antigens were similar for all three groups; however, antigen-negative women, independent of disease status, mounted greater responses to filarial antigen. In contrast, lymphedema patients had higher levels of antifilarial specific IgG1, IgG2, and IgG3 and higher IgG responses to streptolysin O than either Ag- or Mf+ women. In persons with lymphatic filariasis, immune reactivity is influenced by disease status as well as infection status.</div></front></TEI><affiliations><list><country><li>Haïti</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><noCountry><name sortKey="Addiss, David G" sort="Addiss, David G" uniqKey="Addiss D" first="David G." last="Addiss">David G. Addiss</name><name sortKey="Charles, Jacky Louis" sort="Charles, Jacky Louis" uniqKey="Charles J" first="Jacky Louis" last="Charles">Jacky Louis Charles</name><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J." last="Lammie">Patrick J. Lammie</name><name sortKey="Roberts, Jacquelin M" sort="Roberts, Jacquelin M" uniqKey="Roberts J" first="Jacquelin M." last="Roberts">Jacquelin M. Roberts</name><name sortKey="Streit, Thomas G" sort="Streit, Thomas G" uniqKey="Streit T" first="Thomas G." last="Streit">Thomas G. Streit</name></noCountry><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Baird, Jill B" sort="Baird, Jill B" uniqKey="Baird J" first="Jill B." last="Baird">Jill B. Baird</name></region><name sortKey="Baird, Jill B" sort="Baird, Jill B" uniqKey="Baird J" first="Jill B." last="Baird">Jill B. Baird</name><name sortKey="Baird, Jill B" sort="Baird, Jill B" uniqKey="Baird J" first="Jill B." last="Baird">Jill B. Baird</name></country><country name="Haïti"><noRegion><name sortKey="Baird, Jill B" sort="Baird, Jill B" uniqKey="Baird J" first="Jill B." last="Baird">Jill B. Baird</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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